ABSTRACT
This study presents multimodal metaphors as (re)framing tools in the analysis of a 10-minute promotional video of Hubei Province produced by the Chinese government and circulated on new media platforms like YouTube, Douyin (Chinese Tik Tok) and WeChat Channels. The video introduces Hubei Province to the world in the pre-pandemic, pandemic and post-pandemic stage to erase the prejudiced “Wuhan virus” and “China virus” painted by Western media. Drawing upon MIPVU (the Metaphor Identification Procedure Vrije Universitei), multimodality of metaphors, and Critical Discourse Analysis (CDA), this study analyzes how the Chinese government attempts to reframe Hubei as a place of courage, prosperity and humanity via metaphors like WAR, BRIDGE, HAND and BACK. The benefits and drawbacks of such metaphor usage are also discussed with appropriate contextual and socio-cultural relevancies. The study provides a hands-on practice of the CDA-based analysis of multimodal metaphors and justifies the feasibility of integrating translation, metaphor and semiotic studies through the sociological theory of framing. [ FROM AUTHOR] Copyright of Social Semiotics is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
ABSTRACT
The global emergence of SARS-CoV-2 variants has led to increasing breakthrough infections in vaccinated populations, calling for an urgent need to develop more effective and broad-spectrum vaccines to combat COVID-19. Here we report the preclinical development of RQ3013, an mRNA vaccine candidate intended to bring broad protection against SARS-CoV-2 variants of concern (VOCs). RQ3013, which contains pseudouridine-modified mRNAs formulated in lipid nanoparticles, encodes the spike(S) protein harboring a combination of mutations responsible for immune evasion of VOCs. Here we characterized the expressed S immunogen and evaluated the immunogenicity, efficacy, and safety of RQ3013 in various animal models. RQ3013 elicited robust immune responses in mice, hamsters, and nonhuman primates (NHP). It can induce high titers of antibodies with broad cross-neutralizing ability against the Wild-type, B.1.1.7, B.1.351, B.1.617.2, and the omicron B.1.1.529 variants. In mice and NHP, two doses of RQ3013 protected the upper and lower respiratory tract against infection by SARS-CoV-2 and its variants. We also proved the safety of RQ3013 in NHP models. Our results provided key support for the evaluation of RQ3013 in clinical trials.
Subject(s)
Breakthrough Pain , COVID-19ABSTRACT
Drawing upon a corpus approach to metaphor analysis, stance analysis, and Critical Discourse Analysis, the study analyzes different stances taken by the Chinese news outlet Global Times (GT) and the American The New York Times (NYT) in 2020 Coronavirus narratives to Chinese and English readers. The database includes all Coronavirus-related GT and NYT bilingual opinion articles in 2020, that is, 97 pairs from GT and 73 pairs from NYT which are comparable in Chinese and English tokens. Results show that the differences between GT and NYT in narrating the pandemic and the involved parties, that is, China and the US, are statistically significant with a moderate to strong effect size. The Lambda test of association demonstrates that the knowledge of metaphor transfer methods can significantly increase the correctness of attitudinal intensity prediction, which bears out metaphor transfer as a representation of stance mediation.
ABSTRACT
The global emergency caused by the SARS-CoV-2 pandemics can only be solved with adequate preventive and therapeutic strategies, both currently missing. The electropositive Receptor Binding Domain (RBD) of SARS-CoV-2 spike protein with abundant {beta}-sheet structure serves as target for COVID-19 therapeutic drug design. Here, we discovered that ultrathin 2D CuInP2S6 (CIPS) nanosheets as a new agent against SARS-CoV-2 infection, which also able to promote viral host elimination. CIPS exhibits extremely high and selective binding capacity with the RBD of SARS-CoV-2 spike protein, with consequent inhibition of virus entry and infection in ACE2-bearing cells and human airway epithelial organoids. CIPS displays nano-viscous properties in selectively binding with spike protein (KD < 1 pM) with negligible toxicity in vitro and in vivo. Further, the CIPS-bound SARS-CoV-2 was quickly phagocytosed and eliminated by macrophages, suggesting CIPS could be successfully used to capture and facilitate the virus host elimination with possibility of triggering anti-viral immunization. Thus, we propose CIPS as a promising nanodrug for future safe and effective anti-SARS-CoV-2 therapy, as well as for use as disinfection agent and surface coating material to constrain the SARS-CoV-2 spreading.